{"product_id":"usp10-antibody-abccs56252","title":"USP10 Antibody","description":"\u003ch4\u003eSize\u003c\/h4\u003e\u003cp\u003e100ug\u003c\/p\u003e\u003ch4\u003eClone Number\u003c\/h4\u003e\u003cp\u003e\u003c\/p\u003e\u003ch4\u003eAliases\u003c\/h4\u003e\u003cp\u003eDeubiquitinating enzyme 10 antibody; KIAA0190 antibody; MGC124997 antibody; MGC2621 antibody; Ubiquitin carboxyl terminal hydrolase 10 antibody; Ubiquitin carboxyl-terminal hydrolase 10 antibody; Ubiquitin specific peptidase 10 antibody; Ubiquitin specific processing protease 10 antibody; Ubiquitin specific protease 10 antibody; Ubiquitin thioesterase 10 antibody; Ubiquitin thiolesterase 10 antibody; Ubiquitin-specific-processing protease 10 antibody; UBP10_HUMAN antibody; UBPO antibody; USP 10 antibody; USP10 antibody\u003c\/p\u003e\u003ch4\u003eImmunogen Species\u003c\/h4\u003e\u003cp\u003eHomo sapiens (Human)\u003c\/p\u003e\u003ch4\u003eUniProt ID\u003c\/h4\u003e\u003cp\u003eQ14694\u003c\/p\u003e\u003ch4\u003eImmunogen\u003c\/h4\u003e\u003cp\u003eRecombinant Human Ubiquitin carboxyl-terminal hydrolase 10 protein (453-592AA)\u003c\/p\u003e\u003ch4\u003eRaised in\u003c\/h4\u003e\u003cp\u003eRabbit\u003c\/p\u003e\u003ch4\u003eSpecies Reactivity\u003c\/h4\u003e\u003cp\u003eHuman, Rat\u003c\/p\u003e\u003ch4\u003eTested Applications\u003c\/h4\u003e\u003cp\u003eELISA, WB, IHC, IF, IP; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200, IP:1:200-1:2000\u003c\/p\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cp\u003eHydrolase that can remove conjugated ubiquitin from target proteins such as p53\/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53\/TP53 stability: in unstressed cells, specifically deubiquitinates p53\/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53\/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53\/TP53, leading to regulate the p53\/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53\/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3\/VPS34-containing complexes. In turn, PIK3C3\/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3\/VPS34-containing complexes regulate p53\/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989).\u003c\/p\u003e\u003ch4\u003eClonality\u003c\/h4\u003e\u003cp\u003ePolyclonal\u003c\/p\u003e\u003ch4\u003eIsotype\u003c\/h4\u003e\u003cp\u003eIgG\u003c\/p\u003e\u003ch4\u003ePurification Method\u003c\/h4\u003e\u003cp\u003e\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003ch4\u003eConjugate\u003c\/h4\u003e\u003cp\u003eNon-conjugated\u003c\/p\u003e\u003ch4\u003eBuffer\u003c\/h4\u003e\u003cp\u003ePreservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, pH 7.4\u003c\/p\u003e\u003ch4\u003eForm\u003c\/h4\u003e\u003cp\u003eLiquid\u003c\/p\u003e\u003ch4\u003eStroage\u003c\/h4\u003e\u003cp\u003eUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003ch4\u003eTarget Names\u003c\/h4\u003e\u003cp\u003eUSP10\u003c\/p\u003e\u003ch4\u003eResearch Areas\u003c\/h4\u003e\u003cp\u003eEpigenetics and Nuclear Signaling; Cell biology\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"Default Title","offer_id":42288948150506,"sku":"ABCCS56252","price":299.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_649104e7-d5aa-40b2-aaa4-d72a7106371b.png?v=1650882893","url":"https:\/\/danabiosci.com\/products\/usp10-antibody-abccs56252","provider":"Dana Bioscience","version":"1.0","type":"link"}