{"product_id":"ube2n-antibody-abccs56980","title":"UBE2N Antibody","description":"\u003ch4\u003eSize\u003c\/h4\u003e\u003cp\u003e100ug\u003c\/p\u003e\u003ch4\u003eClone Number\u003c\/h4\u003e\u003cp\u003e\u003c\/p\u003e\u003ch4\u003eAliases\u003c\/h4\u003e\u003cp\u003eBendless like ubiquitin conjugating enzyme antibody; Bendless-like ubiquitin-conjugating enzyme antibody; BLU antibody; EC 6.3.2.19 antibody; Epididymis secretory protein Li 71 antibody; HEL-S-71 antibody; Human epidermoid carcinoma mRNA for ubiquitin-conjugating enzyme E2 similar to Drosophila bendless gene product complete cds antibody; MGC131857 antibody; MGC8489 antibody; UBC 13 antibody; Ubc13 antibody; UbCH ben antibody; UbcH-ben antibody; UbcH13 antibody; UBCHBEN antibody; Ube 2N antibody; Ube2n antibody; UBE2N_HUMAN antibody; Ubiquitin carrier protein N antibody; Ubiquitin conjugating enzyme E2 N antibody; Ubiquitin conjugating enzyme E2N (homologous to yeast UBC13) antibody; Ubiquitin conjugating enzyme E2N (UBC13 homolog yeast) antibody; Ubiquitin conjugating enzyme E2N antibody; Ubiquitin protein ligase N antibody; Ubiquitin-conjugating enzyme E2 N antibody; Ubiquitin-protein ligase N antibody; Yeast UBC13 homolog antibody\u003c\/p\u003e\u003ch4\u003eImmunogen Species\u003c\/h4\u003e\u003cp\u003eHomo sapiens (Human)\u003c\/p\u003e\u003ch4\u003eUniProt ID\u003c\/h4\u003e\u003cp\u003eP61088\u003c\/p\u003e\u003ch4\u003eImmunogen\u003c\/h4\u003e\u003cp\u003eRecombinant Human Ubiquitin-conjugating enzyme E2 N protein (20-138AA)\u003c\/p\u003e\u003ch4\u003eRaised in\u003c\/h4\u003e\u003cp\u003eRabbit\u003c\/p\u003e\u003ch4\u003eSpecies Reactivity\u003c\/h4\u003e\u003cp\u003eHuman\u003c\/p\u003e\u003ch4\u003eTested Applications\u003c\/h4\u003e\u003cp\u003eELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200\u003c\/p\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cp\u003eThe UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical \\\\\\'Lys-63\\\\\\'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the \\\\\\'Lys-63\\\\\\'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the \\\\\\'Lys-63\\\\\\'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate \\\\\\'Lys-63\\\\\\'-linked polyubiquitin chains which activate the MAP3K7\/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.\u003c\/p\u003e\u003ch4\u003eClonality\u003c\/h4\u003e\u003cp\u003ePolyclonal\u003c\/p\u003e\u003ch4\u003eIsotype\u003c\/h4\u003e\u003cp\u003eIgG\u003c\/p\u003e\u003ch4\u003ePurification Method\u003c\/h4\u003e\u003cp\u003e\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003ch4\u003eConjugate\u003c\/h4\u003e\u003cp\u003eNon-conjugated\u003c\/p\u003e\u003ch4\u003eBuffer\u003c\/h4\u003e\u003cp\u003ePreservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, pH 7.4\u003c\/p\u003e\u003ch4\u003eForm\u003c\/h4\u003e\u003cp\u003eLiquid\u003c\/p\u003e\u003ch4\u003eStroage\u003c\/h4\u003e\u003cp\u003eUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003ch4\u003eTarget Names\u003c\/h4\u003e\u003cp\u003eUBE2N\u003c\/p\u003e\u003ch4\u003eResearch Areas\u003c\/h4\u003e\u003cp\u003eEpigenetics and Nuclear Signaling; Cell biology; Immunology\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"Default Title","offer_id":42288867606762,"sku":"ABCCS56980","price":299.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_7849ecf5-51b0-4a88-a117-ec34accad55f.png?v=1650884149","url":"https:\/\/danabiosci.com\/products\/ube2n-antibody-abccs56980","provider":"Dana Bioscience","version":"1.0","type":"link"}