{"product_id":"traf2-phospho-ser11-rabbit-polyclonal-antibody-abcb10621","title":"TRAF2(Phospho-Ser11) Rabbit Polyclonal Antibody","description":"\u003ch4\u003eAb type\u003c\/h4\u003e\u003cp\u003ePrimary antibody\u003c\/p\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cp\u003eThe protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with| and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors| and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8\/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs)| and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD| a TNF receptor associated apoptotic signal transducer| ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2\/c-IAP1| an apoptosis inhibitor possessing ubiquitin ligase activity| can unbiquitinate and induce the degradation of this pro\u003c\/p\u003e\u003ch4\u003eReactivity\u003c\/h4\u003e\u003cp\u003eHuman, Mouse\u003c\/p\u003e\u003ch4\u003eClonality\u003c\/h4\u003e\u003cp\u003ePolyclonal\u003c\/p\u003e\u003ch4\u003eHost\u003c\/h4\u003e\u003cp\u003eRabbit\u003c\/p\u003e\u003ch4\u003eIsotype\u003c\/h4\u003e\u003cp\u003eIgG\u003c\/p\u003e\u003ch4\u003eImmunogen\u003c\/h4\u003e\u003cp\u003eSynthesized phosho peptide around human TRAF2 (Ser11) \u003c\/p\u003e\u003ch4\u003eStorage Stability\u003c\/h4\u003e\u003cp\u003e-20°C for 1 year\u003c\/p\u003e\u003ch4\u003eConcentration\u003c\/h4\u003e\u003cp\u003e1 mg\/ml\u003c\/p\u003e\u003ch4\u003eMolecularWeight_Da\u003c\/h4\u003e\u003cp\u003e\u003c\/p\u003e\u003ch4\u003esynonyms\u003c\/h4\u003e\u003cp\u003eTRAF2 ;Ser11 ; TNF receptor-associated factor 2; EC 6.3.2.-; E3 ubiquitin-protein ligase TRAF2; Tumor necrosis factor type 2 receptor-associated protein 3\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":42404761272554,"sku":"ABCB10621","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_7b8c3de8-f869-4cb1-9182-c9c92fbad9d0.png?v=1645228552","url":"https:\/\/danabiosci.com\/products\/traf2-phospho-ser11-rabbit-polyclonal-antibody-abcb10621","provider":"Dana Bioscience","version":"1.0","type":"link"}