{"product_id":"tap1-antibody-abccs44466","title":"TAP1 Antibody","description":"\u003ch4\u003eSize\u003c\/h4\u003e\u003cp\u003e100ul\u003c\/p\u003e\u003ch4\u003eClone Number\u003c\/h4\u003e\u003cp\u003e\u003c\/p\u003e\u003ch4\u003eAliases\u003c\/h4\u003e\u003cp\u003eABC 17 antibody; ABC transporter MHC 1 antibody; ABC17 antibody; ABCB 2 antibody; ABCB2 antibody; Antigen peptide transporter 1 antibody; APT 1 antibody; APT1 antibody; ATP binding cassette sub family B (MDR\/TAP) member 2 antibody; ATP binding cassette sub family B member 2 antibody; ATP binding cassette transporter antibody; ATP-binding cassette sub-family B member 2 antibody; D6S114E antibody; FLJ26666 antibody; FLJ41500 antibody; Peptide supply factor 1 antibody; Peptide transporter involved in antigen processing 1 antibody; Peptide transporter PSF 1 antibody; Peptide transporter PSF1 antibody; Peptide transporter TAP 1 antibody; Peptide transporter TAP1 antibody; PSF 1 antibody; PSF-1 antibody; PSF1 antibody; Really interesting new gene 4 protein antibody; RING 4 antibody; RING4 antibody; TAP 1 antibody; TAP1 antibody; TAP1*0102N antibody; TAP1_HUMAN antibody; TAP1N antibody; Transporter 1 ATP binding cassette sub family B (MDR\/TAP) antibody; Transporter 1 ATP binding cassette sub family B antibody; Transporter associated with antigen processing antibody; Transporter ATP binding cassette major histocompatibility complex 1 antibody; Y3 antibody\u003c\/p\u003e\u003ch4\u003eImmunogen Species\u003c\/h4\u003e\u003cp\u003eHomo sapiens (Human)\u003c\/p\u003e\u003ch4\u003eUniProt ID\u003c\/h4\u003e\u003cp\u003eQ03518\u003c\/p\u003e\u003ch4\u003eImmunogen\u003c\/h4\u003e\u003cp\u003eRecombinant Human Antigen peptide transporter 1 protein (524-808AA)\u003c\/p\u003e\u003ch4\u003eRaised in\u003c\/h4\u003e\u003cp\u003eRabbit\u003c\/p\u003e\u003ch4\u003eSpecies Reactivity\u003c\/h4\u003e\u003cp\u003eHuman\u003c\/p\u003e\u003ch4\u003eTested Applications\u003c\/h4\u003e\u003cp\u003eELISA, IHC; Recommended dilution: IHC:1:20-1:200\u003c\/p\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cp\u003eInvolved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I\/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.\u003c\/p\u003e\u003ch4\u003eClonality\u003c\/h4\u003e\u003cp\u003ePolyclonal\u003c\/p\u003e\u003ch4\u003eIsotype\u003c\/h4\u003e\u003cp\u003eIgG\u003c\/p\u003e\u003ch4\u003ePurification Method\u003c\/h4\u003e\u003cp\u003eAntigen Affinity Purified\u003c\/p\u003e\u003ch4\u003eConjugate\u003c\/h4\u003e\u003cp\u003eNon-conjugated\u003c\/p\u003e\u003ch4\u003eBuffer\u003c\/h4\u003e\u003cp\u003ePBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\u003ch4\u003eForm\u003c\/h4\u003e\u003cp\u003eLiquid\u003c\/p\u003e\u003ch4\u003eStroage\u003c\/h4\u003e\u003cp\u003eUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003ch4\u003eTarget Names\u003c\/h4\u003e\u003cp\u003eTAP1\u003c\/p\u003e\u003ch4\u003eResearch Areas\u003c\/h4\u003e\u003cp\u003eSignal transduction\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"Default Title","offer_id":42359332798698,"sku":"ABCCS44466","price":299.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_a6c8e2f3-b6ec-4b59-aa6f-a532825e7c19.png?v=1650899260","url":"https:\/\/danabiosci.com\/products\/tap1-antibody-abccs44466","provider":"Dana Bioscience","version":"1.0","type":"link"}