{"product_id":"sun2-antibody-abccs60627","title":"SUN2 Antibody","description":"\u003ch4\u003eSize\u003c\/h4\u003e\u003cp\u003e100ug\u003c\/p\u003e\u003ch4\u003eClone Number\u003c\/h4\u003e\u003cp\u003e\u003c\/p\u003e\u003ch4\u003eAliases\u003c\/h4\u003e\u003cp\u003eSUN2 antibody; FRIGG antibody; KIAA0668 antibody; RAB5IP antibody; UNC84B antibody; SUN domain-containing protein 2 antibody; Protein unc-84 homolog B antibody; Rab5-interacting protein antibody; Rab5IP antibody; Sad1\/unc-84 protein-like 2 antibody\u003c\/p\u003e\u003ch4\u003eImmunogen Species\u003c\/h4\u003e\u003cp\u003eHomo sapiens (Human)\u003c\/p\u003e\u003ch4\u003eUniProt ID\u003c\/h4\u003e\u003cp\u003eQ9UH99\u003c\/p\u003e\u003ch4\u003eImmunogen\u003c\/h4\u003e\u003cp\u003eRecombinant Human SUN domain-containing protein 2 protein (45-155AA)\u003c\/p\u003e\u003ch4\u003eRaised in\u003c\/h4\u003e\u003cp\u003eRabbit\u003c\/p\u003e\u003ch4\u003eSpecies Reactivity\u003c\/h4\u003e\u003cp\u003eHuman, Mouse, Rat\u003c\/p\u003e\u003ch4\u003eTested Applications\u003c\/h4\u003e\u003cp\u003eELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500\u003c\/p\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cp\u003eAs a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1\/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.\u003c\/p\u003e\u003ch4\u003eClonality\u003c\/h4\u003e\u003cp\u003ePolyclonal\u003c\/p\u003e\u003ch4\u003eIsotype\u003c\/h4\u003e\u003cp\u003eIgG\u003c\/p\u003e\u003ch4\u003ePurification Method\u003c\/h4\u003e\u003cp\u003e\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003ch4\u003eConjugate\u003c\/h4\u003e\u003cp\u003eNon-conjugated\u003c\/p\u003e\u003ch4\u003eBuffer\u003c\/h4\u003e\u003cp\u003ePreservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, pH 7.4\u003c\/p\u003e\u003ch4\u003eForm\u003c\/h4\u003e\u003cp\u003eLiquid\u003c\/p\u003e\u003ch4\u003eStroage\u003c\/h4\u003e\u003cp\u003eUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003ch4\u003eTarget Names\u003c\/h4\u003e\u003cp\u003eSUN2\u003c\/p\u003e\u003ch4\u003eResearch Areas\u003c\/h4\u003e\u003cp\u003eTags \u0026amp; Cell Markers; Signal transduction\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"Default Title","offer_id":42271871009002,"sku":"ABCCS60627","price":299.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_3c22ca60-2fc5-4e67-83f8-63637e649426.png?v=1650617708","url":"https:\/\/danabiosci.com\/products\/sun2-antibody-abccs60627","provider":"Dana Bioscience","version":"1.0","type":"link"}