{"product_id":"stat2-acetyl-lys384-rabbit-polyclonal-antibody-abcb10306","title":"Stat2 (Acetyl Lys384) Rabbit Polyclonal Antibody","description":"\u003ch4\u003eAb type\u003c\/h4\u003e\u003cp\u003ePrimary antibody\u003c\/p\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cp\u003eSignal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors| Jak kinases (TYK2 and JAK1) are activated| leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize| associate with ISGF3G\/IRF-9 to form a complex termed ISGF3 transcription factor| that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes| which drive the cell in an antiviral state.|PTM:Tyrosine phosphorylated in response to IFN-alpha.|Belongs to the transcription factor STAT family.|Contains 1 SH2 domain.|subcellular location:Translocated into the nucleus upon activation by IFN-alpha\/beta.|subunit:Interacts with ISGF3G\/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha\/beta induced phosphorylation. Interacts with CRSP2 and CRSP6. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein.|\u003c\/p\u003e\u003ch4\u003eReactivity\u003c\/h4\u003e\u003cp\u003eHuman, Rat\u003c\/p\u003e\u003ch4\u003eClonality\u003c\/h4\u003e\u003cp\u003ePolyclonal\u003c\/p\u003e\u003ch4\u003eHost\u003c\/h4\u003e\u003cp\u003eRabbit\u003c\/p\u003e\u003ch4\u003eIsotype\u003c\/h4\u003e\u003cp\u003eIgG\u003c\/p\u003e\u003ch4\u003eImmunogen\u003c\/h4\u003e\u003cp\u003eSynthesized peptide derived from human Stat2 (Acetyl Lys384)\u003c\/p\u003e\u003ch4\u003eStorage Stability\u003c\/h4\u003e\u003cp\u003e-20°C for 1 year\u003c\/p\u003e\u003ch4\u003eConcentration\u003c\/h4\u003e\u003cp\u003e1 mg\/ml\u003c\/p\u003e\u003ch4\u003eMolecularWeight_Da\u003c\/h4\u003e\u003cp\u003e93610\u003c\/p\u003e\u003ch4\u003esynonyms\u003c\/h4\u003e\u003cp\u003eStat2 ;Acetyl Lys384; Signal transducer and activator of transcription 2; p113\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":42404739547370,"sku":"ABCB10306","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_b4ac2790-d65d-4865-9a40-94fa7217fcc2.png?v=1645228081","url":"https:\/\/danabiosci.com\/products\/stat2-acetyl-lys384-rabbit-polyclonal-antibody-abcb10306","provider":"Dana Bioscience","version":"1.0","type":"link"}