{"product_id":"smad7-acetyl-lys70-rabbit-polyclonal-antibody-abcb10163","title":"Smad7 (Acetyl Lys70) Rabbit Polyclonal Antibody","description":"\u003ch4\u003eAb type\u003c\/h4\u003e\u003cp\u003ePrimary antibody\u003c\/p\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cp\u003eThe protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding| this complex translocates to the cytoplasm| where it interacts with TGF-beta receptor type-1 (TGFBR1)| leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. \u003c\/p\u003e\u003ch4\u003eReactivity\u003c\/h4\u003e\u003cp\u003eHuman, Mouse, Rat\u003c\/p\u003e\u003ch4\u003eClonality\u003c\/h4\u003e\u003cp\u003ePolyclonal\u003c\/p\u003e\u003ch4\u003eHost\u003c\/h4\u003e\u003cp\u003eRabbit\u003c\/p\u003e\u003ch4\u003eIsotype\u003c\/h4\u003e\u003cp\u003eIgG\u003c\/p\u003e\u003ch4\u003eImmunogen\u003c\/h4\u003e\u003cp\u003eSynthesized peptide derived from human Smad7 (Acetyl Lys70)\u003c\/p\u003e\u003ch4\u003eStorage Stability\u003c\/h4\u003e\u003cp\u003e-20°C for 1 year\u003c\/p\u003e\u003ch4\u003eConcentration\u003c\/h4\u003e\u003cp\u003e1 mg\/ml\u003c\/p\u003e\u003ch4\u003eMolecularWeight_Da\u003c\/h4\u003e\u003cp\u003e46860\u003c\/p\u003e\u003ch4\u003esynonyms\u003c\/h4\u003e\u003cp\u003eSmad7 ;Acetyl Lys70; Mothers against decapentaplegic homolog 7; MAD homolog 7; Mothers against DPP homolog 7; Mothers against decapentaplegic homolog 8; MAD homolog 8; Mothers against DPP homolog 8; SMAD family member 7; SMAD 7; Smad7; hSMAD7\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":42404733190378,"sku":"ABCB10163","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_167a034a-6eac-4163-8608-53f07346aa37.png?v=1645227871","url":"https:\/\/danabiosci.com\/products\/smad7-acetyl-lys70-rabbit-polyclonal-antibody-abcb10163","provider":"Dana Bioscience","version":"1.0","type":"link"}