{"product_id":"sik1-polyclonal-antibody-abcb14921","title":"SIK1 Polyclonal Antibody","description":"\u003ch4\u003eAb type\u003c\/h4\u003e\u003cp\u003ePrimary antibody\u003c\/p\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cp\u003eCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-182 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,Transient role during the earliest stages of myocardial cell differentiation and\/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and\/or differentiation. Potential role in G2\/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,Belongs to the protein kinase superfamily. CAMK Ser\/Thr protein kinase family. AMPK subfamily.,Contains 1 protein kinase domain.,Contains 1 UBA domain.,subcellular location:Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ.,subunit:Binds to and is activated by YWHAZ when phosphorylated on Thr-182.,\u003c\/p\u003e\u003ch4\u003eReactivity\u003c\/h4\u003e\u003cp\u003eHuman, Mouse, Rat\u003c\/p\u003e\u003ch4\u003eClonality\u003c\/h4\u003e\u003cp\u003ePolyclonal\u003c\/p\u003e\u003ch4\u003eHost\u003c\/h4\u003e\u003cp\u003eRabbit\u003c\/p\u003e\u003ch4\u003eIsotype\u003c\/h4\u003e\u003cp\u003eIgG\u003c\/p\u003e\u003ch4\u003eImmunogen\u003c\/h4\u003e\u003cp\u003eSynthesized peptide derived from human protein . at AA range: 130-210\u003c\/p\u003e\u003ch4\u003eStorage Stability\u003c\/h4\u003e\u003cp\u003e-20°C for 1 year\u003c\/p\u003e\u003ch4\u003eConcentration\u003c\/h4\u003e\u003cp\u003e1 mg\/ml\u003c\/p\u003e\u003ch4\u003eMolecularWeight_Da\u003c\/h4\u003e\u003cp\u003e\u003c\/p\u003e\u003ch4\u003esynonyms\u003c\/h4\u003e\u003cp\u003eSerine\/threonine-protein kinase SIK1 ;EC 2.7.11.1;Salt-inducible kinase 1;SIK-1;Serine\/threonine-protein kinase SNF1-like kinase 1;Serine\/threonine-protein kinase SNF1LK\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"100ul \/ Rabbit \/ Primary antibody","offer_id":42405154554090,"sku":"ABCB14921","price":275.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_67e900ed-e92f-4669-80de-1663c983e0e3.png?v=1645235279","url":"https:\/\/danabiosci.com\/products\/sik1-polyclonal-antibody-abcb14921","provider":"Dana Bioscience","version":"1.0","type":"link"}