{"product_id":"rq8244","title":"PPP1R15B Antibody \/ Protein phosphatase 1 regulatory subunit 15B","description":"\u003cp\u003ePPP1R15B (Protein phosphatase 1, regulatory subunit 15b), also called CREP, promotes dephosphorylation of the transcription initiation factor EIF2-alpha through recruitment of protein phosphatase-1 (PP1) catalytic subunits. The PPP1R15B gene is mapped to chromosome 1q32.1 based on an alignment of the PPP1R15B sequence by Hartz(2010). Harding et al.(2009) obtained Ppp1r15b -\/- mice at a mendelian ratio. However, Ppp1r15b -\/- newborns were half the size of their wildtype littermates, were notably pale, and failed to nurse, and none survived the first day of postnatal life. Ppp1r15b -\/- embryos that were also homozygous for an Eif2-alpha mutation that prevented Eif2-alpha phosphorylation were normalized, including elevated birth size and restored red blood cell count, compared with Ppp1r15b -\/- embryos with wildtype Eif2-alpha.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49475332440344,"sku":"RQ8244","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_3876d2d1-e8ae-4099-b76e-c0003a75dcb7.jpg?v=1734446723","url":"https:\/\/danabiosci.com\/products\/rq8244","provider":"Dana Bioscience","version":"1.0","type":"link"}