{"product_id":"rq8209","title":"SESN1 Antibody \/ Sestrin 1 \/ SEST1 \/ PA26","description":"\u003cp\u003eSestrin 1, also known as p53-regulated protein PA26 and SEST1, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49475335225624,"sku":"RQ8209","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_0a04c0f1-a073-49cf-b306-3e2ed6b7668e.jpg?v=1734446833","url":"https:\/\/danabiosci.com\/products\/rq8209","provider":"Dana Bioscience","version":"1.0","type":"link"}