{"product_id":"rq8151","title":"PSMC4 Antibody \/ 26S proteasome regulatory subunit 6B \/ TBP-7","description":"\u003cp\u003e26S protease regulatory subunit 6B, also known as 26S proteasome AAA-ATPase subunit Rpt3 and Tat-binding protein 7 (TBP-7), is an enzyme that in humans is encoded by the PSMC4 gene. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP\/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49475338371352,"sku":"RQ8151","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_8897e6c3-89b4-4977-9a43-89bf330f4516.jpg?v=1734447011","url":"https:\/\/danabiosci.com\/products\/rq8151","provider":"Dana Bioscience","version":"1.0","type":"link"}