{"product_id":"rq7208","title":"TLR4 Antibody","description":"\u003cp\u003eTLR4, the human homolog of Drosophila Toll, is a type I transmembrane protein with an extracellular domain consisting of a leucine-rich repeat region and an intracellular domain homologous to that of human interleukin-1 receptor. The TLR4 gene is mapped to chromosome 9q32-q33 by fluorescence in situ hybridization. It detects lipopolysaccharide from Gram-negative bacteria and is thus important in the activation of the innate immune system. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns(PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49475437756696,"sku":"RQ7208","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_b7e20c1b-0ad3-466f-b7ab-4b1d516695b8.jpg?v=1734450256","url":"https:\/\/danabiosci.com\/products\/rq7208","provider":"Dana Bioscience","version":"1.0","type":"link"}