{"product_id":"rq6569","title":"FAM129B Antibody \/ MINERVA \/ NIBAN2","description":"\u003cp\u003eFAM129B\/Niban-like protein 1 (family with sequence similarity 129, member B) belongs to a poorly characterized family of Niban proteins that also includes FAM129A\/Niban and FAM129C\/Niban-like protein 2. FAM129A\/Niban is implicated in the ER stress response and is upregulated at the protein level in thyroid carcinoma. FAM129C\/Niban-like protein 2 is preferentially expressed in B-cells and is one of five biomarkers upregulated in whole blood from patients with colorectal carcinoma. FAM129B is broadly expressed and has been shown to be a downstream target of B-Raf in melanoma cells. Though FAM129B does not appear to regulate cell growth and division, phosphorylation of FAM129B by B-Raf is essential for the invasive potential of melanoma and non-melanoma cell lines. Deletion of FAM129B in melanoma cells significantly impairs B-Raf\/MEK\/Erk-dependent invasion into the extracellular matrix.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49475847913752,"sku":"RQ6569","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_7e13b78c-ce23-41d9-9d1c-95723d18189a.jpg?v=1734461165","url":"https:\/\/danabiosci.com\/products\/rq6569","provider":"Dana Bioscience","version":"1.0","type":"link"}