{"product_id":"rq6474","title":"SGT1 Antibody \/ ECD","description":"\u003cp\u003eProtein SGT1 is a protein that in humans is encoded by the ECD gene. Regulator of p53\/TP53 stability and function. Inhibits MDM2-mediated degradation of p53\/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49475855515928,"sku":"RQ6474","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_9f974973-449e-41f3-8df9-14d41400541b.jpg?v=1734461490","url":"https:\/\/danabiosci.com\/products\/rq6474","provider":"Dana Bioscience","version":"1.0","type":"link"}