{"product_id":"rq5549","title":"SIRT1 Antibody","description":"\u003cp\u003eSirtuin 1, also known as SIR2L1 or SIRT1, is a protein that in humans is encoded by the SIRT1 gene. It is mapped to 10q21.3. Sirtuin 1 is a member of the sirtuin family of proteins, homologs of the Sir2 gene in S. cerevisiae. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. Sirtuin 1 is downregulated in cells that have high insulin resistance and inducing its expression increases insulin sensitivity, suggesting the molecule is associated with improving insulin sensitivity. Furthermore, Sirtuin 1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha\/ERR-alpha complex, which are essential metabolic regulatory transcription factors.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49475964207384,"sku":"RQ5549","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_a2826541-f74d-4d15-949a-bca0af8b6a9c.jpg?v=1734464617","url":"https:\/\/danabiosci.com\/products\/rq5549","provider":"Dana Bioscience","version":"1.0","type":"link"}