{"product_id":"rq5483","title":"CTLA-4 Antibody \/ CD152","description":"\u003cp\u003eThe CTLA4 gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [RefSeq]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ul \/ Rabbit","offer_id":49475969188120,"sku":"RQ5483","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_b6e91615-953a-4663-878c-d38682388b42.jpg?v=1734464824","url":"https:\/\/danabiosci.com\/products\/rq5483","provider":"Dana Bioscience","version":"1.0","type":"link"}