{"product_id":"rq5292","title":"Arachidonate 5-Lipoxygenase Antibody \/ ALOX5","description":"\u003cp\u003eThe ALOX5 gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. [RefSeq]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ul \/ Rabbit","offer_id":49475983966488,"sku":"RQ5292","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_781f2a7e-23c9-41cd-a9ff-ee2f5da68143.jpg?v=1734465321","url":"https:\/\/danabiosci.com\/products\/rq5292","provider":"Dana Bioscience","version":"1.0","type":"link"}