{"product_id":"rq5288","title":"Cleaved PARP1 Antibody","description":"\u003cp\u003eThe main role of PARP (found in the cell nucleus) is to detect and initiate an immediate cellular response to metabolic, chemical, or radiation-induced single-strand DNA breaks (SSB) by signaling the enzymatic machinery involved in the SSB repair. [Wiki] Cleavage of PARP, by enzymes such as caspases or cathepsins, typically inactivates PARP. While in vitro cleavage by caspase occurs throughout the caspase family, preliminary data suggest that caspase-3 and caspase-7 are responsible for in vivo cleavage. Cleavage occurs at aspartic acid 214 and glycine 215, separating PARP into a 24kDA and 89kDA segment. The smaller moiety includes the zinc finger motif requisite in DNA binding. The 89 kDa fragment includes the auto-modification domain and catalytic domain. [Wiki]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ul \/ Rabbit","offer_id":49475984490776,"sku":"RQ5288","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_05470862-be5a-4d1d-9386-f04ee4157498.jpg?v=1734465332","url":"https:\/\/danabiosci.com\/products\/rq5288","provider":"Dana Bioscience","version":"1.0","type":"link"}