{"product_id":"rq5083","title":"Thymidylate Synthase Antibody","description":"\u003cp\u003eThymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1, vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [RefSeq]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ul \/ Rabbit","offer_id":49476005429528,"sku":"RQ5083","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_37771c95-3759-4160-ab2e-4249a567faed.jpg?v=1734465841","url":"https:\/\/danabiosci.com\/products\/rq5083","provider":"Dana Bioscience","version":"1.0","type":"link"}