{"product_id":"rq4044","title":"SMAD1 \/ SMAD5 Antibody","description":"\u003cp\u003eSMADs are proteins that modulate the activity of transforming growth factor beta ligands. The SMADs, often in complex with other SMADs\/CoSMAD, act as transcription factors that regulate the expression of certain genes. It was concluded that targeted ubiquitination of SMADs may serve to control both embryonic development and a wide variety of cellular responses to TGF-beta signals. R-Smads or receptor regulated Smads are a class of proteins that include SMAD1, SMAD2, SMAD3, SMAD5, and SMAD8. In response to signals by the TGF-? superfamily of ligands these proteins associate with receptor kinases and are phosphorylated at an SSXS motif at their extreme C-terminus. These proteins then typically bind to the common mediator Smad or co-SMAD SMAD4.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49476163272984,"sku":"RQ4044","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_7eca96b8-9bef-4d33-b560-578d9004a610.jpg?v=1734468762","url":"https:\/\/danabiosci.com\/products\/rq4044","provider":"Dana Bioscience","version":"1.0","type":"link"}