{"product_id":"rnf5-antibody-abccs46363","title":"RNF5 Antibody","description":"\u003ch4\u003eSize\u003c\/h4\u003e\u003cp\u003e100ul\u003c\/p\u003e\u003ch4\u003eClone Number\u003c\/h4\u003e\u003cp\u003e\u003c\/p\u003e\u003ch4\u003eAliases\u003c\/h4\u003e\u003cp\u003eE3 ubiquitin protein ligase RNF5 antibody; E3 ubiquitin-protein ligase RNF5 antibody; G16 antibody; HsRma1 antibody; NG2 antibody; OTTHUMP00000029107 antibody; Protein G16 antibody; Ram1 homolog antibody; RING finger protein 5 antibody; RING5 antibody; RMA1 antibody; RNF 5 antibody; RNF5 antibody; RNF5_HUMAN antibody\u003c\/p\u003e\u003ch4\u003eImmunogen Species\u003c\/h4\u003e\u003cp\u003eHomo sapiens (Human)\u003c\/p\u003e\u003ch4\u003eUniProt ID\u003c\/h4\u003e\u003cp\u003eQ99942\u003c\/p\u003e\u003ch4\u003eImmunogen\u003c\/h4\u003e\u003cp\u003eRecombinant Human E3 ubiquitin-protein ligase RNF5 protein (1-120AA)\u003c\/p\u003e\u003ch4\u003eRaised in\u003c\/h4\u003e\u003cp\u003eRabbit\u003c\/p\u003e\u003ch4\u003eSpecies Reactivity\u003c\/h4\u003e\u003cp\u003eHuman, Mouse\u003c\/p\u003e\u003ch4\u003eTested Applications\u003c\/h4\u003e\u003cp\u003eELISA, WB, IHC, IF; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200\u003c\/p\u003e\u003ch4\u003eBackground\u003c\/h4\u003e\u003cp\u003eHas E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1\/UBCH5A and UBE2D2\/UBC4. Mediates ubiquitination of PXN\/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN\/paxillin. Mediates the \\\\\\'Lys-63\\\\\\'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the \\\\\\'Lys-48\\\\\\'-linked polyubiquitination of TMEM173 at \\\\\\'Lys-150\\\\\\' leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses.\u003c\/p\u003e\u003ch4\u003eClonality\u003c\/h4\u003e\u003cp\u003ePolyclonal\u003c\/p\u003e\u003ch4\u003eIsotype\u003c\/h4\u003e\u003cp\u003eIgG\u003c\/p\u003e\u003ch4\u003ePurification Method\u003c\/h4\u003e\u003cp\u003eAntigen Affinity Purified\u003c\/p\u003e\u003ch4\u003eConjugate\u003c\/h4\u003e\u003cp\u003eNon-conjugated\u003c\/p\u003e\u003ch4\u003eBuffer\u003c\/h4\u003e\u003cp\u003ePBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\u003ch4\u003eForm\u003c\/h4\u003e\u003cp\u003eLiquid\u003c\/p\u003e\u003ch4\u003eStroage\u003c\/h4\u003e\u003cp\u003eUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003ch4\u003eTarget Names\u003c\/h4\u003e\u003cp\u003eRNF5\u003c\/p\u003e\u003ch4\u003eResearch Areas\u003c\/h4\u003e\u003cp\u003eCancer; Cell biology; Immunology; Microbiology\u003c\/p\u003e","brand":"ABCbiolab","offers":[{"title":"Default Title","offer_id":42344537063658,"sku":"ABCCS46363","price":299.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/products\/758-7580448_monoclonal-antibody-png-transparent-png_e7029f98-682f-4e56-a786-92420f7204b4.png?v=1650903023","url":"https:\/\/danabiosci.com\/products\/rnf5-antibody-abccs46363","provider":"Dana Bioscience","version":"1.0","type":"link"}