{"product_id":"r32586","title":"ATF4 Antibody","description":"\u003cp\u003eATF4, Activating Transcription Factor 4, is also known as CREB2. ATF4 belongs to the large ATF\/CREB family of transcription factors which bind DNA via their basic region and dimerize via their leucine zipper domain to form a variety of homo- and heterodimers to regulate gene transcription. It is identified that members of this family share significant sequence similarity within a leucine zipper DNA-binding motif and an adjacent basic region. The ATF4 gene is mapped to chromosome 22. Unlike CREB, which activates transcription from CRE-containing promoters, CREB2 functions as a specific repressor of CRE-dependent transcription. The transcriptional repressor activity resides within the C-terminal leucine zipper and basic domain region of the CREB2 protein.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49476651843864,"sku":"R32586","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_7e26ed2d-9eb6-4236-9a6d-83496c59a4da.jpg?v=1734478713","url":"https:\/\/danabiosci.com\/products\/r32586","provider":"Dana Bioscience","version":"1.0","type":"link"}