{"product_id":"r32238","title":"SMAD Antibody (SMAD1-5)","description":"\u003cp\u003eSMADs are proteins that modulate the activity of transforming growth factor beta ligands. The SMADs, often in complex with other SMADs\/CoSMAD, act as transcription factors that regulate the expression of certain genes. It was concluded that targeted ubiquitination of SMADs may serve to control both embryonic development and a wide variety of cellular responses to TGF-beta signals. R-Smads or receptor regulated Smads are a class of proteins that include SMAD1, SMAD2, SMAD3, SMAD5, and SMAD8. In response to signals by the TGF-beta superfamily of ligands these proteins associate with receptor kinases and are phosphorylated at an SSXS motif at their extreme C-terminus. These proteins then typically bind to the common mediator Smad or co-SMAD SMAD4.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49476686643480,"sku":"R32238","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_b230bbe3-d436-44a8-afd0-f82f1391b635.jpg?v=1734479801","url":"https:\/\/danabiosci.com\/products\/r32238","provider":"Dana Bioscience","version":"1.0","type":"link"}