{"product_id":"r31750","title":"HSP60 Antibody","description":"HSP60 is a member of the chaperonin class of protein factors, which include the Escherichia coli groEL protein and the Rubisco subunit-binding protein of chloroplasts. It acts as a costimulator of human regulatory CD4-positive\/CD25 -positive T cells, which inhibit lymphoproliferation and IFNG and TNF secretion by CD4-positive and CD8-positive T cells. HSP60 enhances Treg activity via TLR2, leading to activation of an intracellular signaling cascade that included p38, as well as inhibition of ERK phosphorylation. Suppression of target T cells is mediated by both cell-to-cell contact and by secretion of TGFB and IL10, and it leads to downregulation of ERK, \u003ca href=\"..\/search_result.php?search_txt=nfkb\"\u003eNFKB\u003c\/a\u003e, and \u003ca href=\"..\/search_result.php?search_txt=tbet\"\u003eTBET\u003c\/a\u003e expression. The self-molecule HSP60 can downregulate adaptive immune responses by upregulating Tregs through \u003ca href=\"..\/search_result.php?search_txt=tlr2\"\u003eTLR2\u003c\/a\u003esignaling.","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49476733862168,"sku":"R31750","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_f63e27f8-dd2e-408b-bee2-811d4dd63e13.jpg?v=1734481298","url":"https:\/\/danabiosci.com\/products\/r31750","provider":"Dana Bioscience","version":"1.0","type":"link"}