{"product_id":"r31705","title":"IkB beta Antibody","description":"NF-kappa-B inhibitor beta, also known as IKBB or TRIP9, is a protein that in humans is encoded by the NFKBIB gene. The protein encoded by this gene belongs to the \u003ca href=\"..\/search_result.php?search_txt=nfkb\"\u003eNF-kappa-B\u003c\/a\u003e inhibitor family, which inhibit NF-kappa-B by complexing with it and therebye trapping it in the cytoplasm. It has been found that in vivo, IkB beta serves both to inhibit and to facilitate the inflammatory response. Its degradation releases NF-kappa-B dimers, which upregulate proinflammatory target genes such as \u003ca href=\"..\/search_result.php?search_txt=tnf\" alpha\u003eTNF-alpha\u003c\/a\u003e. Surprisingly, absence of IkB beta results in a dramatic reduction of TNF-alpha in response to lipopolysaccharide, even though activation of NF-kappa-B is normal.","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49476736385304,"sku":"R31705","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_289875a5-a407-4a70-9152-f4eddfa1d375.jpg?v=1734481424","url":"https:\/\/danabiosci.com\/products\/r31705","provider":"Dana Bioscience","version":"1.0","type":"link"}