{"product_id":"r31578","title":"SIRT1 Antibody","description":"\u003cp\u003eSirtuin 1, also known as SIR2L1, is a protein that in humans is encoded by the SIRT1 gene. Sirtuin 1 is a member of the sirtuin family of proteins, homologs of the Sir2 gene in S. cerevisiae. Family members are characterized by a sirtuin core domain and grouped into four classes. Sirtuin 1 is downregulated in cells that have high insulin resistance and inducing its expression increases insulin sensitivity, suggesting the molecule is associated with improving insulin sensitivity. Furthermore, SIRT1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha\/ERR-alpha complex, which are essential metabolic regulatory transcription factors.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49476742218008,"sku":"R31578","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_eb43efec-c2b5-4524-9890-755c1ebf4546.jpg?v=1734481784","url":"https:\/\/danabiosci.com\/products\/r31578","provider":"Dana Bioscience","version":"1.0","type":"link"}