{"product_id":"r31414","title":"DOG1 Antibody (TMEM16A)","description":"\u003cp\u003eAnoctamin-1 (ANO1), also known as oral cancer overexpressed 2 (ORAOV2), Tumor-amplified and overexpressed sequence 2 (TMEM16A), and Discovered on gastrointestinal stromal tumors protein 1 (DOG1) is a protein that in humans is encoded by the ANO1 gene. This gene belongs to a family of membrane proteins containing 8 transmembrane segments, and it is mapped to 11q13.3. ANO1 is a candidate calcium-activated chloride channel that mediates receptor-activated chloride currents in diverse physiologic processes, and it is though to be responsible for a voltage-sensitive calcium-activated chloride current. Its overexpression was reported in esophageal squamous cell carcinoma and breast cancer progression Crofelemer, an antidiarrhoeal, inhibits this channel. ANO1\/DOG1 has eight transmembrane domains, its pore is large and non-selective, allowing other negatively charged species to permeate.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49476749885720,"sku":"R31414","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_aaa79f72-3815-4883-9519-007f64ec4a34.jpg?v=1734482215","url":"https:\/\/danabiosci.com\/products\/r31414","provider":"Dana Bioscience","version":"1.0","type":"link"}