TIA-1 Antibody

TIA-1 (T-Cell Intracellular Antigen-1), also called WDM, is an RNA-binding protein involved in splicing regulation and translational repression. It is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte(CTL) target cells. By in situ hybridization, the gene is mapped to chromosome 2p13.3. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is though to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.