{"product_id":"r31198","title":"Proprotein Convertase 4 Antibody","description":"\u003cp\u003eProprotein Convertase, Subtilisin\/Kexin-Type, 4, is an enzyme that in humans is encoded by the PCSK4 gene. The gene was mapped to mouse chromosome 10, close to the adipsin locus and near the gene encoding anti-mullerian hormone. Qiu et al.(2005) found that aberrant processing of pro-IGF2 may be a cause of IUGR. PCSK4 cleaved pro-IGF2 to generate the intermediate processed form, IGF2(1-102). Mature IGF2(1-67), likely resulting from further processing by carboxypeptidases, is capable of activating invasive trophoblast cells through AKT phosphorylation. Inhibition of the protein by a PCSK4-specific inhibitor blocked pro-IGF2 processing and reduced trophoblast cell migration.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49476759945496,"sku":"R31198","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_26f0c57f-75fa-4b17-b94a-ed1ef851ff2e.jpg?v=1734482689","url":"https:\/\/danabiosci.com\/products\/r31198","provider":"Dana Bioscience","version":"1.0","type":"link"}