{"product_id":"r31196","title":"Proprotein Convertase 1\/3 Antibody","description":"\u003cp\u003eProprotein Convertase, Subtilisin\/Kexin-Type, 1, also known as PC1 or NEC1, is an enzyme that in humans is encoded by the PCSK1 gene. It is a neuroendocrine convertase that belongs to a family of subtilisin-like serine endoproteases that process large precursor proteins into mature bioactive products. By in situ hybridization, Seidah et al.(1991) mapped the gene to human chromosome 5q15-q21 and mouse chromosome 13. Ohagi et al.(1996) noted that PCSK1 initiates the sequential processing of proinsulin to insulin by cleaving the proinsulin molecule on the C-terminal side of the dibasic peptide, arg31-arg32, joining the B-chain and C-peptide. By observing the phenotypic features in patients with PCSK1 mutations, Jackson et al.(2003) concluded that human intestinal absorptive function is dependent on the enzymes activity.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49476760011032,"sku":"R31196","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_de78a3a2-ef02-47b8-b626-9daa32651158.jpg?v=1734482692","url":"https:\/\/danabiosci.com\/products\/r31196","provider":"Dana Bioscience","version":"1.0","type":"link"}