{"product_id":"r31002","title":"TRIF Antibody","description":"TIR Domain-containing adaptor molecule 1, also known as TICAM1 or TRIF, is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter. By genomic sequence analysis, Oshiumi et al.(2003) mapped the gene to chromosome 19p13.3. By coimmunoprecipitation analysis, Oshiumi et al.(2003) showed that the protein interacts specifically with \u003ca href=\"..\/search_result.php?search_txt=TLR3\"\u003eTLR3\u003c\/a\u003e, but not with other TLRs. Functional analysis showed that the association of TLR3 and TRIF mediates dsRNA activation of IFNB, through either \u003ca href=\"..\/search_result.php?search_txt=nfkb\"\u003eNFKB\u003c\/a\u003e, \u003ca href=\"..\/search_result.php?search_txt=ap1\"\u003eAP1\u003c\/a\u003e, or \u003ca href=\"..\/search_result.php?search_txt=irf3\"\u003eIRF3\u003c\/a\u003e. TRIF activation of NFKB was found to occur predominantly through \u003ca href=\"..\/search_result.php?search_txt=irak1\"\u003eIRAK1\u003c\/a\u003e rather than \u003ca href=\"..\/search_result.php?search_txt=irak2\"\u003eIRAK2\u003c\/a\u003e. siRNA blockage of the protein reduced IFNB production in response to dsRNA.","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49476777247000,"sku":"R31002","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_a18c0fec-46bb-42d3-a493-328cd845bee6.jpg?v=1734483124","url":"https:\/\/danabiosci.com\/products\/r31002","provider":"Dana Bioscience","version":"1.0","type":"link"}