{"product_id":"r30981","title":"ERBB4 Antibody (HER4)","description":"\u003cp\u003eV-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4, also known as HER4, is an enzyme that in humans is encoded by the ERBB4 gene. The HER4\/ERBB4 gene is a member of the type I receptor tyrosine kinase subfamily that includes EGFR, ERBB2 and ERBB3. ERBB4 is a single-pass type I transmembrane protein with multiplefurin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and aPDZ domainbinding motif.Huang et al.(2000) reported that the proteinis enriched in the postsynaptic density and associates with PSD95. Itis a transmembrane receptor tyrosine kinase that regulates cell proliferation and differentiation. After binding its ligand, heregulin, or activation of protein kinase C by TPA, the ERBB4 ectodomain is cleaved by a metalloprotease. Ni et al.(2001)concluded that gamma-secretase cleavage ofthe proteinmay represent another mechanism for receptor tyrosine kinase-mediated signaling.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49476779737368,"sku":"R30981","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_db19de37-a5f4-4607-8e19-3fa096005c16.jpg?v=1734483167","url":"https:\/\/danabiosci.com\/products\/r30981","provider":"Dana Bioscience","version":"1.0","type":"link"}