{"product_id":"r30901","title":"RelB Antibody","description":"\u003cp\u003eRelB (v-rel reticuloendotheliosis viral oncogene homolog B) is also known as IREL. By RT-PCR and immunocytochemical analyses, Clark et al.(1999) showed that protein expression correlated with dendritic cell activation. NF-kappa-B-inducing kinase is required for osteoclastogenesis in response to pathologic stimuli. Vaira et al.(2008) found that overexpression of RelB, but not RelA, rescued differentiation of mouse Nik -\/- osteoclast precursors, indicating that blockade of the alternative NF-kappa-B pathway, rather than the classic pathway, is responsible for the osteoclastogenic defect in the absence of Nik. Using RelB -\/- mice, they showed that the protein itself was required for RankL-induced osteoclastogenesis in vitro and for TNF-induced bone resorption in vivo. Both RelB -\/- and Nik -\/- mice were resistant to tumor-mediated osteolysis. Vaira et al.(2008) concluded that the alternative NF-kappa-B pathway, via RelB, plays an essential and unique role in RankL signaling toward osteoclast development.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49476795072792,"sku":"R30901","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_fb7fe647-99d7-4599-8467-be4d54afe712.jpg?v=1734483390","url":"https:\/\/danabiosci.com\/products\/r30901","provider":"Dana Bioscience","version":"1.0","type":"link"}