{"product_id":"r30745","title":"MyD88 Antibody","description":"Myeloid differentiation primary response gene 88 is a protein that in humans is encoded by the MYD88 gene. MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 receptors(IL1Rs). It a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and\u003ca href=\"..\/tlr-toll-like-receptor-antibodies.html\"\u003eToll-like receptor\u003c\/a\u003esignaling pathways. Qverexpression causes an increase in the level of transcription from the interleukin-8 promoter. The C-terminal domain of the protein has significant sequence similarity to the cytoplasmic domain of IL1RAP. Inhibiting the IL1R-MyD88 pathway in vivo could block the damage from acute inflammation that occurs in response to sterile cell death, and do so in a way that might not compromise tissue repair or host defense against pathogens.","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49476815847704,"sku":"R30745","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_9d2b7fec-2def-42bf-afe4-a31db2763698.jpg?v=1734483743","url":"https:\/\/danabiosci.com\/products\/r30745","provider":"Dana Bioscience","version":"1.0","type":"link"}