{"product_id":"r30724","title":"Ku80 Antibody","description":"\u003cp\u003eXRCC5 (X-ray Repair, Complementing Defective, In Chinese Hamster, 5), also known as Ku80 or Ku86, is a protein that in humans, is encoded by the XRCC5 gene. The XRCC5 gene encodes the 80-kD subunit of the Ku autoantigen, a heterodimer which contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the nonhomologous end joining(NHEJ) pathway. Human colon cancer cells heterozygous for Ku80 are haploinsufficient with an increase in polyploid cells, a reduction in cell proliferation, elevated p53 levels, and a slight hypersensitivity to ionizing radiation. Functional inactivation of the second Ku80 allele results in cells with a drastically reduced doubling time. The locus is essential in human somatic tissue culture cells by experiments demonstration. A rare microsatellite polymorphism in the protein is associated with cancer in patients of varying radiosensitivity.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49476816404760,"sku":"R30724","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_149fb036-3860-4de5-ab06-57722ef75381.jpg?v=1734483795","url":"https:\/\/danabiosci.com\/products\/r30724","provider":"Dana Bioscience","version":"1.0","type":"link"}