{"product_id":"r30673","title":"Caspase-9 Antibody","description":"Caspase-9, also called APAF3, is an initiator caspase, encoded by the CASP9 gene. The gene is mapped to chromosome 1p36.3-p36.1 by FISH. CASP9 is identified as a member of the caspase family that participates in \u003ca href=\"..\/search_result.php?search_txt=caspase-3\"\u003eCASP3\u003c\/a\u003e activation in vitro. And it also regarded as the most upstream member of the apoptotic protease cascade that is triggered by Cytochrome C and dATP. The crystal structure of CASP9 is complex with the BIR3 in an inhibitory domain of XIAP at 2.4-angstrom resolution and the gene contains 9 exons and spans approximately 35 kb of genomic DNA. Caspase-9 and APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of \u003ca href=\"..\/search_result.php?search_txt=cytochrome%20c\"\u003eCytochrome C\u003c\/a\u003e and dATP, an event that leads to CASP9 activation. Activity increases dramatically upon association with the apoptosome complex. And the majority of CASP9 knockout mice died perinatally with a markedly enlarged and malformed cerebrum caused by reduced apoptosis during brain development.","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49476818272536,"sku":"R30673","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_9e7bb142-a0c2-4748-8853-e758df3b2253.jpg?v=1734483907","url":"https:\/\/danabiosci.com\/products\/r30673","provider":"Dana Bioscience","version":"1.0","type":"link"}