{"product_id":"r30294","title":"Estrogen Receptor Antibody (beta)","description":"Estrogen receptor-beta, referred to as ESR2 or ER\u003cfont face=\"symbol\"\u003eb\u003c\/font\u003e, is a member of the superfamily of nuclear receptors which can transduce extracellular signals into transcriptional responses. This gene is mapped to 14q and comprises 8 exons spanning approximately 40 kb. It is expressed in multiple tissues, including developing spermatids of the testis and in ovarian granulosa cells. ER\u003cfont face=\"symbol\"\u003eb\u003c\/font\u003e is homologous to the previously identified ER\u003cfont face=\"symbol\"\u003ea\u003c\/font\u003e and has an overlapping but nonidentical tissue distribution. The DNA-binding domain of ER\u003cfont face=\"symbol\"\u003eb\u003c\/font\u003e is 96% conserved compared to ER\u003cfont face=\"symbol\"\u003ea\u003c\/font\u003e, and the ligand-binding domain shows 58% conserved residues. Estrogen receptor beta is expressed in human thymus, spleen, ovary, and testis. ER\u003cfont face=\"symbol\"\u003eb\u003c\/font\u003e mRNA was coexpressed with ER\u003cfont face=\"symbol\"\u003ea\u003c\/font\u003e and its splice variants in 60% of prolactinomas, 100% of mixed growth hormone \/prolactin tumors, and 29% of gonadotroph tumors. Gene expression was not limited to ERa-positive tumor subtypes, however, and was also found in 100% of null cell tumors, 80% of somatotroph tumors, and 60% of corticotroph tumors.","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49476838523160,"sku":"R30294","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_faee43a2-a157-4bda-856d-a10202e35764.jpg?v=1734484711","url":"https:\/\/danabiosci.com\/products\/r30294","provider":"Dana Bioscience","version":"1.0","type":"link"}