{"product_id":"r30228","title":"MAPK1\/3 Antibody","description":"\u003cp\u003eMAPK1(ERK2) shares high homology with MAPK3(ERK1). MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Mitogen-activated protein(MAP) kinases [also known as Erks] have been established to function as important mediators of signal transduction by growth factor receptors. ERK1\/ERK2-dependent activation of endogenous ribosomal transcription, while inactivation of ERK1\/ERK2 causes an equally immediate reversion to the basal transcription level. ERK1\/ERK2 was found to phosphorylate the architectural transcription factor UBF at amino acids 117 and 201 within HMG boxes 1 and 2, preventing their interaction with DNA. Mutation of these sites inhibited transcription activation and abrogated the transcriptional response to ERK1\/ERK2.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49476846977304,"sku":"R30228","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_6158d885-f089-4d8d-876b-28e7b26e90b6.jpg?v=1734484844","url":"https:\/\/danabiosci.com\/products\/r30228","provider":"Dana Bioscience","version":"1.0","type":"link"}