{"product_id":"r30138","title":"TIE2 Antibody","description":"Tyrosine kinase with Ig and EGF homology domains 2, also known as TEK tyrosine kinase, is a receptor that belongs to the Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand \u003ca href=\"..\/search_result.php?search_txt=ang1\"\u003eAngiopoietin-1\u003c\/a\u003e binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Rabbit","offer_id":49476899111192,"sku":"R30138","price":439.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_1d6d557e-f2d9-428d-bcad-7b14dd5e047b.jpg?v=1734485020","url":"https:\/\/danabiosci.com\/products\/r30138","provider":"Dana Bioscience","version":"1.0","type":"link"}