{"product_id":"r30048","title":"MAP Kinase Antibody, Activated (Diphosphorylated ERK-1\u00262)","description":"\u003cp\u003eIn mammalian cells, a variety of extracellular stimuli generate intracellular signals that converge on a limited number of so-called mitogen-activated protein(MAP) kinase pathways. The central core of each MAP kinase(MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase(MAPKKK) phosphorylates and activates a specific MAPK kinase(MAPKK), which then activates a specific MAPK. Mek1\/2 MAPK kinases are essential for mammalian development, homeostasis, and Raf-induced hyperplasia. Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug \/ Mouse","offer_id":49476955963672,"sku":"R30048","price":439.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/danabiosci.com\/products\/r30048","provider":"Dana Bioscience","version":"1.0","type":"link"}