{"product_id":"prp1928-1mg","title":"Human Galectin-8 Protein, His tag (Animal-Free)","description":"\u003cp\u003eGalectin-8 (Gal-8) is a lectin family member and is one of the tandem repeat-type galectins containing two carbohydrate recognition domains (CRD) connected by a linker region in a single peptide chain. The CRD is responsible for β-galactoside binding, and the binding partners for galectin-8 have been identified, including CD44 and a subset of integrins. Galectin-8 and integrins form complexes, subsequently leading to phosphorylation of paxillin and focal adhesion kinase (FAK), which activates signal pathways including MAPK-ERK and PI3K-AKT pathways. Galectin-8 is constitutively presented in the Liver, kidney, cardiac muscle, lung, and brain. Galectin-8 serves as an immunosuppressive protective role against autoimmune CNS inflammation, regulating the balance of Th17 and Th1 polarization.\u003c\/p\u003e","brand":"Abbkine","offers":[{"title":"1 mg","offer_id":50419248464152,"sku":"PRP1928-1mg","price":0.0,"currency_code":"USD","in_stock":false}],"url":"https:\/\/danabiosci.com\/products\/prp1928-1mg","provider":"Dana Bioscience","version":"1.0","type":"link"}