{"product_id":"prp1122-1mg","title":"Human RSPO1\/R-spondin 1 Protein, His-SUMO tag (Animal-Free)","description":"\u003cp\u003eR-spondin 1 (RSPO1, Roof plate-specific Spondin 1) is a cysteine-rich secreted glycoprotein that belongs to the R-Spondin family. Structurally, R-spondin 1 harbors an N-terminal signal peptide, two cysteine-rich furin-like (FU1-FU2) domains, a thrombospondin (TSP) domain, and a basic amino acid-rich (BR) C-terminal domain. R-spondin 1 acts as a ligand for the leucine-rich repeat-containing G-protein coupled receptor (LGR) family (LGR4\/5\/6), subsequent clearing negative regulators ZNRF3\/RNF43 from the membrane, leading to the availability of Wnt receptor and activating Wnt\/β-catenin signaling. The signal cascade is essential for regulating stem cell proliferation, embryonic development, and tissue homeostasis.\u003c\/p\u003e","brand":"Abbkine","offers":[{"title":"1 mg","offer_id":50419251085592,"sku":"PRP1122-1mg","price":0.0,"currency_code":"USD","in_stock":false}],"url":"https:\/\/danabiosci.com\/products\/prp1122-1mg","provider":"Dana Bioscience","version":"1.0","type":"link"}