{"product_id":"pemax-mrna-m1ψ-substitution","title":"PEmax mRNA ( m1ψ substitution )","description":"\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003e\u003cspan\u003ePEmax represents a significant architectural optimization of the PE2 system. By incorporating an additional Nuclear Localization Signal (NLS) and a refined nCas9 domain, it achieves superior nuclear import and targeting efficiency. Unlike traditional CRISPR methods, PEmax enables precise genomic modifications without inducing double-stranded breaks (DSBs), thereby maximizing editing yield and broadening the scope of targetable base conversions with enhanced fidelity. Synthesized via in vitro transcription with a Cap 1 structure and poly(A) tail, it mimics mature mRNA to enhance stability, translation efficiency, and performance while minimizing immune responses.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cmeta charset=\"utf-8\"\u003e\n\u003cstrong\u003emRNA Length:\u003c\/strong\u003e\u003cbr\u003e9289 nt\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eBase Composition:\u003c\/strong\u003e\u003cbr\u003eN1-Me-pUTP (N1-mψ)\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eConcentration:\u003c\/strong\u003e\u003cbr\u003e1.0 mg\/ mL\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eCap Modification:\u003c\/strong\u003e\u003cbr\u003eCap 1 structure\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003ePoly A Tail:\u003c\/strong\u003e\u003cbr\u003eYes\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eForm:\u003c\/strong\u003e\u003cbr\u003eLiquid\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eBuffer:\u003c\/strong\u003e\u003cbr\u003e1 mM sodium citrate buffer, pH 6.4.\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e\u003cbr\u003eProducts can be stored at -80°C or below.\u003cbr\u003eWe recommend to aliquot the mRNA solution for a better storage. Avoid repeated freeze\/thaw cycles.\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eShipping:\u003c\/strong\u003e\u003cbr\u003eThe products are shipped on dry ice and should be avoided for freeze-thaw cycles.\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eApplication:\u003c\/strong\u003e\u003cbr\u003eGene editing\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eShipping Conditions:\u003c\/strong\u003e\u003cbr\u003eDry ice\u003c\/span\u003e\u003c\/p\u003e","brand":"Croyezbio","offers":[{"title":"100 ug","offer_id":52165166432536,"sku":"CR00048-100UG","price":833.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":52165166465304,"sku":"CR00048-1MG","price":5000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/15403790.png?v=1781091289","url":"https:\/\/danabiosci.com\/products\/pemax-mrna-m1%cf%88-substitution","provider":"Dana Bioscience","version":"1.0","type":"link"}