{"product_id":"nsj-v9710-100ug","title":"BCL11A Antibody \/ B-cell lymphoma\/leukemia 11A, 100 ug","description":"\u003cp\u003eBcl-11a (CtIP-1, EVI9, B cell chronic lymphocytic leukemia (CLL)\/lymphoma 11A) and Bcl-11b (CtIP-2, RIT1, B cell CLL\/lymphoma 11B) genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51547690696984,"sku":"V9710-100UG","price":559.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_56e015db-4ca4-494b-93e6-5bcce34da936.jpg?v=1768265988","url":"https:\/\/danabiosci.com\/products\/nsj-v9710-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}