{"product_id":"nsj-v8700-20ug","title":"IL1A Antibody \/ IL1 alpha, 20 ug","description":"\u003cp\u003eTwo forms of interleukin-1, designated IL-1 alpha and beta, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1a and IL-1b bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression. IL-1 induces B cell proliferation and maturation, and immunoglobulin synthesis. NK cells require IL-1 for production of the anti-pathogen IFN-. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug","offer_id":51547994390808,"sku":"V8700-20UG","price":259.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_2a7b66f7-42a2-470d-bca5-6a3f721953fa.jpg?v=1768270651","url":"https:\/\/danabiosci.com\/products\/nsj-v8700-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}