{"product_id":"nsj-v8495-20ug","title":"TIM3 Antibody \/ HAVCR2, 20 ug","description":"\u003cp\u003eTIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser\/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cel tonsil, lymph node or spleen. In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation and cytotoxicity, regulatory T cell development, and increases in macrophage and neutrophil infiltration into sites of inflammation.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug","offer_id":51548020179224,"sku":"V8495-20UG","price":259.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_418b14c9-dcaf-4368-977b-9c9101f8fc9d.jpg?v=1768271453","url":"https:\/\/danabiosci.com\/products\/nsj-v8495-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}