{"product_id":"nsj-v8291-20ug","title":"Cig2 Antibody, 20 ug","description":"\u003cp\u003eCig2 is a cyclin that functions as the catalytic subunit of cyclin-dependent kinases (Cdks) in the fission yeast Schizosaccharomyces pombe. It is a B-type, S phase cyclin that is required for both the G1\/S and G2\/M cell cycle transitions and is expressed in a sharp spike that peaks during the G1\/S period. Cig2 binds to Cdc2 (Cdk), and the resulting Cdc2\/Cig2 complex controls the G1\/S transition of the cell cycle. Disruption of Cig2 delays the onset of mitosis. The expression of the Cig2 gene is dependent on Mlu1-binding factor (MBF), and the protein is destroyed during anaphase by the APC\/cyclosome (APC\/C) and Skp1\/Cullin-1\/F-box (SCF), thereby ensuring the spike expression pattern of Cig2. SCF regulates Cig2 levels in a dual manner, transcriptionally and post-translationally, while APC\/C only destroys the protein.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug","offer_id":51548046393624,"sku":"V8291-20UG","price":259.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_8d250993-697d-4095-8eca-212f25dc9ec4.jpg?v=1768272225","url":"https:\/\/danabiosci.com\/products\/nsj-v8291-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}