{"product_id":"nsj-v8108-20ug","title":"TAL1 Antibody \/ T-cell acute lymphocytic leukemia protein 1, 20 ug","description":"\u003cp\u003eActivation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB\/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase II, a serine\/threonine protein kinase known to modulate the activity of other HLH transcription factors.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug","offer_id":51548066513176,"sku":"V8108-20UG","price":259.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_440b8a7e-bdd0-48c0-90b9-c6197e417f0b.jpg?v=1768272945","url":"https:\/\/danabiosci.com\/products\/nsj-v8108-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}