{"product_id":"nsj-v8041-20ug","title":"PTPN6 Antibody \/ SHP-1, 20 ug","description":"\u003cp\u003ePTPN6, which is also designated as SHP-1, is expressed primarily in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. It maps to 12p13, a region commonly involved in leukemia-associated chromosomal abnormalities. SHP-1 plays a role in modulating intracellular signaling for various molecules. In T-cell lymphomas and other malignancies, SHP-1 phosphatase expression is lost, by a thus far undetermined mechanism. Preliminary studies suggest that it may be helpful in differentiating mantle\/marginal zone lymphomas (SHP-1+) from follicular lymphomas (SHP-1 negative).\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug","offer_id":51548076081432,"sku":"V8041-20UG","price":259.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_c8c276ab-3b08-4369-a047-5564454a363a.jpg?v=1768273210","url":"https:\/\/danabiosci.com\/products\/nsj-v8041-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}