{"product_id":"nsj-v7966-20ug","title":"MTF1 Antibody \/ Metal regulatory transcription factor 1, 20 ug","description":"\u003cp\u003eThe metal-responsive element (MRE)-binding transcription factor (MTF-1) stimulates the expression of metallothioneins in response to the exposure of cells to heavy metals. MTF-1 contains six zinc fingers in the DNA binding domain. The phosphorylation of MTF-1 in response to metal exposure appears to play a significant role in the ability of MTF-1 to activate metallothionein transcription. In addition to its role in metallothionein activation, MTF-1 is involved in a post-transcription regulatory complex for ribosomal protein S25. MTF-1, La and p53 inhibit the nuclear export of S25 mRNA in response to nutrient depravation. Furthermore, MTF-1 acts as a chromatin insulator on integrated transgenes in cultured cells to insulate active loci against chromatin silencing.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug","offer_id":51548084306200,"sku":"V7966-20UG","price":259.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_bd7524ed-2b73-4b0f-ae4f-66afdaf36de2.jpg?v=1768273547","url":"https:\/\/danabiosci.com\/products\/nsj-v7966-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}